Abstract
Therapeutic interventions that can delay age associated diseases and ensure a longer health-span is a major goal of aging research. Consequent to understanding that aging is a modifiable trait, a large number of studies are currently being undertaken to elucidate the mechanism(s) of the aging process. Research on human aging and longevity is difficult, due to longer time frame, ethical concerns and environmental variables. Most of the present day understanding about the aging process comes through studies conducted on model organisms. These provide suitable platforms for understanding underlying mechanism(s) which control aging and have led to major discoveries that emphasize the evolutionarily conserved molecular pathways as key players that respond to extra and intracellular signals. This is a review of various invertebrate and vertebrate models including yeast, Drosophila, C. elegans, rodents, naked mole rat, and birds, currently used in aging research with emphasis on how well they can mimic aging in higher animals and humans.
Highlights
Invertebrate and vertebrate models in aging researchTherapeutic interventions that can delay age associated diseases and ensure a longer health-span is a major goal of aging research
A major part of biological research on aging has largely focused on healthspan and lifespan extension
Many theories suggest the aging process was a function of natural selection in favor of evolutionary benefits, the data from studies of model organisms have established that the rate of aging exhibits plasticity and that the rate of oxygen free radical generation during cellular respiration determines the rate of aging[3]
Summary
Therapeutic interventions that can delay age associated diseases and ensure a longer health-span is a major goal of aging research. Most of the present day understanding about the aging process comes through studies conducted on model organisms These provide suitable platforms for understanding underlying mechanism(s) which control aging and have led to major discoveries that emphasize the evolutionarily conserved molecular pathways as key players that respond to extra and intracellular signals. This is a review of various invertebrate and vertebrate models including yeast, Drosophila, C. elegans, rodents, naked mole rat, and birds, currently used in aging research with emphasis on how well they can mimic aging in higher animals and humans.
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