Abstract
Background T1-mapping has great diagnostic potential based on tight normal ranges and excellent sensitivity to disease. Numerically, T1 calculation hinges on the inversion time (TI) from the inversion preparation to the centre of k-space for each T1-weighted image. In the original ShMOLLI sequence (Piechnik JCMR 2010, 12:69) based on “Work In Progress” WIP561 MOLLI, the TI calculation was offset from centre of k-space by two SSFP echo spacings, and included ~10ms duration of the adiabatic inversion pulse itself. The impact on T1 values resulting from rectifying this since WIP448B and WIP780 warrants investigation to assure an accurate clinical interpretation of previously published normal ranges of MOLLI T1 values.
Highlights
T1-mapping has great diagnostic potential based on tight normal ranges and excellent sensitivity to disease
The novel ShMOLLI variant (WIP448C) produced lower T1 estimates compared to original ShMOLLI (WIP561)
This is especially pronounced for the short T1 range, both in the pre-contrast environment and all post-contrast T1 estimates (ΔT1= -25±8ms)
Summary
T1-mapping has great diagnostic potential based on tight normal ranges and excellent sensitivity to disease. T1 calculation hinges on the inversion time (TI) from the inversion preparation to the centre of k-space for each T1-weighted image. In the original ShMOLLI sequence (Piechnik JCMR 2010, 12:69) based on “Work In Progress” WIP561 MOLLI, the TI calculation was offset from centre of k-space by two SSFP echo spacings, and included ~10ms duration of the adiabatic inversion pulse itself. The impact on T1 values resulting from rectifying this since WIP448B and WIP780 warrants investigation to assure an accurate clinical interpretation of previously published normal ranges of MOLLI T1 values
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