Abstract
Wnt ligands are palmitoylated glycoproteins that regulate essential aspects of early development, including embryonic patterning, cell proliferation and cell fate determination. Wnts are secreted and bind to cell-surface heptahelical receptors termed Frizzleds. To date 10 Frizzled (Fzd) receptors have been identified in mice and men. Depending on the receptor context, Wnt ligands can initiate at least three different intracellular signaling cascades: The Wnt/β-catenin pathway, the Wnt/Planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway.
Highlights
12th Joint Meeting of the Signal Transduction Society (STS)
Signal Transduction: Receptors, Mediators and Genes Frank Entschladen, Karlheinz Friedrich, Ralf Hass and Ottmar Janssen Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
We analyzed the regulation of the β-catenin pathway in the context of M. tuberculosis infections: After aerosol infection of mice we find an inverse regulation of the Toll-like receptors (TLR)/NF-κB- and the Wnt/β-catenin pathway: Whereas inducible nitric oxide synthase and IFN-γ formation are increased, β-catenin levels and the transcription of β-catenin dependent target genes are significantly reduced
Summary
12th Joint Meeting of the Signal Transduction Society (STS). Signal Transduction: Receptors, Mediators and Genes Frank Entschladen, Karlheinz Friedrich, Ralf Hass and Ottmar Janssen Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. . Inverse relationship of TLR/NF-κB signalling and the Wnt/β-catenin pathway during inflammation: Deciphering the role of Frizzled1 in Signal Transduction: Receptors, Mediators and Genes Weimar, Germany. Signal Transduction: Receptors, Mediators and Genes Frank Entschladen, Karlheinz Friedrich, Ralf Hass and Ottmar Janssen Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
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