Abstract
Metabolic syndrome (MetS) has been identified to be associated with a state of chronic, low-grade inflammation in adipose tissue. Lipoxins are endogenously generated from arachidonic acid, and exhibit anti-inflammatory actions. Currently, there is no available cohort study identifying the association between serum lipoxins level and MetS. Here we investigate the relationship between serum lipoxin A4 (LXA4) level and the risk of incident MetS in a middle-aged Chinese population. A total 624 participants aged 40–65 years were enrolled at baseline, with 417 (including 333 MetS absence) of them were followed up at 2.5 years. Abdominal visceral fat area (VFA) and abdominal subcutaneous fat area (SFA) were determined using MRI. Serum lipoxin A4 levels were measured by ELISA. At baseline, serum LXA4 levels were significantly correlated with a cluster of traditional MetS risk factors related to obesity (P≤0.05). A higher incidence of new Mets was found in the participants of the lowest tertile of LXA4 levels as compared with that in participants of the highest tertile (P = 0.025). Low serum LXA4 levels [OR 2.607(1.151–5.909), P = 0.022] and high VFA [OR 2.571(1.176–5.620), P = 0.018] were associated with an increased incident Mets, respectively, which remained statistically significant after adjustment for age, gender, current smoking, and alcohol drinking status. Logistic regression analysis suggested a combination of low serum LXA4 levels and high WC/VFA might optimize the prediction of incident Mets in middle-aged Chinese population [OR 4.897/4.967, P = 0.009/0.003]. Decrease in serum LXA4 level and increase in VFA are independent predictors of incident Mets in a population-based cohort, and a combination of them enhances the prognostic value of incident Mets. Taken together, our data suggest that serum LXA4 levels might be useful for early detection and prevention of Mets.
Highlights
Metabolic syndrome (MetS) has received increased attention in the past decade
Because abdominal obesity plays an important role in the development of MetS and we have found a close relationship between visceral fat area (VFA)/waist circumference (WC) and serum lipoxin A4 (LXA4) levels, we further assessed whether a low level of serum LXA4 could effectively predict the risk of incident MetS
When participants were classified into four groups according to the combination of serum LXA4 levels and VFA, risk of MetS among the four groups showed the similar trend to the results described above: the incidence of MetS in participants with a low LXA4 and high VFA was highest among the four groups at 2.5-year follow-up, with 4.967 times higher risk of
Summary
Metabolic syndrome (MetS) has received increased attention in the past decade. Patients with MetS are at increased risk for developing type 2 diabetes mellitus (T2DM) and atheroscleroticPLOS ONE | DOI:10.1371/journal.pone.0142848 November 13, 2015Serum Lipoxin A4 and MetS cardiovascular disease. Metabolic syndrome (MetS) has received increased attention in the past decade. Patients with MetS are at increased risk for developing type 2 diabetes mellitus (T2DM) and atherosclerotic. Serum Lipoxin A4 and MetS cardiovascular disease. Decreased insulin sensitivity is the central feature of this syndrome. This syndrome has been noted to be associated with a state of chronic, low-grade inflammation, in which macrophages accumulate in adipose tissue and secrete inflammatory cytokines. Adipose inflammation is considered to be associated with insulin resistance[1,2,3]. The available evidence supports the concept that targeting inflammation improves insulin sensitivity and βcell function; it ameliorates glucose control in patients with MetS or T2DM[4, 5]
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