Inverse psoriasis and psoriasis of ‘difficult’ localizations: Effectiveness of netakimab

Abstract

Introduction. The drug netakimab belongs to the group of IL-17A blockers and has shown high efficacy against all clinical symptoms of psoriasis vulgaris according to clinical trials and real clinical practice. At the same time, data on the effectiveness of netakimab in inverse psoriasis, psoriasis of ‘difficult’ localizations are of a single nature, while these phenotypes, as a rule, proceed torpidly and constantly recur, which makes it possible to attribute them to severe forms and to consider the appointment of genetically engineered drugs in the first line of systemic treatment.Material and methods. The study included 68 patients with various localizations of psoriasis vulgaris (scalp, palms and soles), psoriatic onychodystrophy and inverse psoriasis. Psoriasis vulgaris with lesions of the scalp was observed in 28 (41.2%) patients, with lesions of the palms and soles – in 24 (35.3%). Inverse psoriasis was diagnosed in 37 (54.4%) patients. Psoriatic onychodystrophy was observed in 44 (64.7%) patients and was combined with both psoriasis vulgaris and inverse psoriasis. All patients were prescribed netakimab.Results. In the group of patients with inverse psoriasis, 81.1% of patients achieved sPGA scores of 0 after 12 weeks. In 71.4% of patients with psoriasis of the scalp, in 75% of patients with palmar-plantar psoriasis, it was possible to achieve complete control over the disease sPGA 0 points. The number of patients with NAPSI less than 5 points was 70.5%.Conclusions. The data presented in the article confirm the high efficacy of netakimab in the treatment of scalp psoriasis, palmoplantar psoriasis, with inverse forms and psoriatic onychodystrophy.