Abstract
The current field of targeted drug design is predominantly focused on protein-ligand interactions, not just because of historical reasons but especially because of the prevailing inability to selectively target biological membranes beyond the level of molecular structure. Design of (peptide) drugs that selectively target distinct, collective structural features in biological lipid membranes such as leaflet curvature is severely challenged by the dynamic, disordered fluid nature of lipid membranes.
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