Abstract
The dynamical fluctuations in the rhythms of biological systems provide valuable information about the underlying functioning of these systems. During the past few decades analysis of cardiac function based on the heart rate variability (HRV; variation in R wave to R wave intervals) has attracted great attention, resulting in more than 17000-publications (PubMed list). However, it is still controversial about the underling mechanisms of HRV. In this study, we performed both linear (time domain and frequency domain) and nonlinear analysis of HRV data acquired from humans and animals to identify the relationship between HRV and heart rate (HR). The HRV data consists of the following groups: (a) human normal sinus rhythm (n = 72); (b) human congestive heart failure (n = 44); (c) rabbit sinoatrial node cells (SANC; n = 67); (d) conscious rat (n = 11). In both human and animal data at variant pathological conditions, both linear and nonlinear analysis techniques showed an inverse correlation between HRV and HR, supporting the concept that HRV is dependent on HR, and therefore, HRV cannot be used in an ordinary manner to analyse autonomic nerve activity of a heart.
Highlights
Greek Physicians and scientists were the pioneers who measured pulse rate; it was not much accurate till the invention of pulse watch in 1707 [1]
In both human and animal data at variant pathological conditions, both linear and nonlinear analysis techniques showed an inverse correlation between heart rate variability (HRV) and heart rate (HR), supporting the concept that HRV is dependent on HR, and HRV cannot be used in an ordinary manner to analyse autonomic nerve activity of a heart
HRV in terms of SDNN and RMSSD is high in rabbit sinoatrial node cells (SANC) (Fig 1C, 1I and 1J) conscious rat (Fig 1D, 1I and 1J)
Summary
Greek Physicians and scientists were the pioneers who measured pulse rate; it was not much accurate till the invention of pulse watch in 1707 [1]. PLOS ONE | DOI:10.1371/journal.pone.0157557 June 23, 2016
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