Abstract
The objective of this study was to vary the wall thicknesses and pore sizes of inversely printed 3D molded bodies. Wall thicknesses were varied from 1500 to 2000 to 2500 µm. The pores had sizes of 500, 750 and 1000 µm. The sacrificial structures were fabricated from polylactide (PLA) using fused deposition modeling (FDM). To obtain the final bioceramic scaffolds, a water-based slurry was filled into the PLA molds. The PLA sacrificial molds were burned out at approximately 450 °C for 4 h. Subsequently, the samples were sintered at 1250 °C for at least 4 h. The scaffolds were mechanically characterized (native and after incubation in simulated body fluid (SBF) for 28 days). In addition, the biocompatibility was assessed by live/dead staining. The scaffolds with a strand spacing of 500 µm showed the highest compressive strength; there was no significant difference in compressive strength regardless of pore size. The specimens with 1000 µm pore size showed a significant dependence on strand width. Thus, the specimens (1000 µm pores) with 2500 µm wall thickness showed the highest compressive strength of 5.97 + 0.89 MPa. While the 1000(1500) showed a value of 2.90 + 0.67 MPa and the 1000(2000) of 3.49 + 1.16 MPa. As expected for beta-Tricalciumphosphate (β-TCP), very good biocompatibility was observed with increasing cell numbers over the experimental period.
Highlights
Published: 14 April 2021Diseases and defects of the skeletal system continue to increase in our society
We describe the fabrication principle of the 3D printed Calcium phosphates (CaP) molded bodies used for this project elsewhere [39,40,41]
As in previous studies [39], the samples with 500 μm pore size were found to have the smallest dimensions compared to the samples with larger pores (750 and 1000 μm)
Summary
Diseases and defects of the skeletal system continue to increase in our society. Only 128,932 knee arthroplasties, as well as 194,453 hip arthroplasties, were implanted in 2004 [3]. In terms of knee arthroplasties, this corresponds to an increase of one third and one fifth for hip arthroplasties within. For example, are used for the heads of hip joint implants due to their high strength [4,5]. Bioglass [7], biosilicates (like calcium silicate) [8,9] or calcium-based ceramics (e.g., calcium sulphates [10], calcium phosphates [11]) are used as coatings for implants to achieve better ingrowth of the bone
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