Abstract
Objective: Our study includes the investigation of the phytochemical composition and in vitro free radical content and antiinflammatory activity of Mimosa pudica. Materials and Method: Free radical scavenging assay was done to evaluate the dose dependent reduction of free radical by ethanolic extract of Mimosa pudica, this activity was compared with a reference antioxidant i.e. Ascorbic acid. The anti-inflammatory potential of ethanolic extract of Mimosa pudica has been determined by using carrageenan-induced paw edema assay and Cotton wool granuloma in rats. Results: The IC50 of our sample was 24.55 μg/ml, it’s a very much promising result comparing to same reference. At the dose of 300 mg/kg the extract shows considerable inhibitory effect on paw increase 1 hour after carrageenan administration, by inhibiting nearly 50%. The maximum inhibition (43.48%; p Conclusion: This finding suggests that ethanolic extract of M. pudica possess potent anti-inflammatory activity possibly due to its free radical scavenging properties. Key words: Anti-oxidant, Carrageenan, Cotton oil, Inflammation, Mimosa pudica, Paw edema.
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