Invasive pneumococcal disease in children can reveal a primary immunodeficiency.

Abstract

J Gaschignard, C Levy, M Chrabieh. Clin Infect Dis. 2014;59(2):244–251 The goal of this study was to investigate all children hospitalized in France with invasive pneumococcal disease for possible immunodeficiency. A total of 163 children were hospitalized in 28 pediatric wards throughout France between 2005 and 2011. A French national cooperative prospectively identified hospitalized patients with invasive pneumococcal disease that was based on the isolation of Streptococcus pneumoniae from an otherwise sterile site. Patients with HIV disease or sickle cell anemia were excluded. Clinical and family history, as well as pneumococcal vaccination status, was documented in all patients; laboratory studies included white blood cell counts, immunoglobulin levels, complement …