Abstract
Micro papillary carcinoma (MC) has been recently recognized as a rare distinctive variant of adenocarcinoma. It is considered as an aggressive variant with a high incidence of lymph node metastasis, only few cases of colorectal MC have been reported. Recently it has been officially recognized in WHO classification We present a case of MC of the sigmoid colon with extensive lymph node metastasis. A 61-year-old female patient was admitted with a complaint of acute abdomen diagnosed as MC of the sigmoid colon. The patient underwent Left hemi colectomy with lymph node dissection.
Highlights
Invasive micro papillary carcinoma (IMPC) has been recently recognized by WHO as a rare distinctive and aggressive variant of adenocarcinoma
With high incidence of lymph node and distant metastasis, it was first described in breast, but recently been reported in other organs such as lungs, urinary bladder, ovaries or salivary glands
It carries worse Prognosis than conventional colorectal carcinoma [1]. It is characterized by mall clusters of malignant cells with abundant eosinophilic cytoplasm and pleomorphic nuclei, micropapillae inhabit lacunar-like spaces and demonstrate a "reverse polarity" configuration, with apical surfaces facing the periphery rather than the center
Summary
Invasive micro papillary carcinoma (IMPC) has been recently recognized by WHO as a rare distinctive and aggressive variant of adenocarcinoma. With high incidence of lymph node and distant metastasis, it was first described in breast, but recently been reported in other organs such as lungs, urinary bladder, ovaries or salivary glands It carries worse Prognosis than conventional colorectal carcinoma [1]. On the day of admission her symptoms get worst and started to be anuric for 24 hours and she got chest pain She gave a history of significant weight loss and appetite during last 2 years. Characterized by Small clusters of malignant cells with abundant eosinophilic cytoplasm and pleomorphic nuclei Micro papillae inhabit lacunar-like spaces and demonstrate a "reversepolarity" configuration, with apical surfaces facing the periphery rather than the center (Figure 2). Endothelial marker (CD31) was negative in the tumor cluster at the lacunar space, but positive in true lympho vascular invasion
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