Abstract
In Reply. —The importance of GBS as a cause of maternal morbidity is well recognized. As pointed out by Dr Greenspoon, the incidence of invasive GBS maternal infection may be underestimated in our study since cultures were not obtained from all febrile patients; this comment may apply as well to other groups of patients such as diabetics with skin and soft tissue infections. Our data provide an estimate of definite cases of GBS disease in pregnancy and in other conditions. We agree with the need for preventive strategies to decrease morbidity from GBS infections in pregnant women. However, the optimal approach is not clear. While prophylactic antibiotics for women colonized with GBS may prevent infection, the potential benefit must be balanced against cost and the risk of adverse drug reactions. If intrapartum antibiotics were given to all women colonized with GBS, it seems likely that the adverse effects would outweigh
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