Abstract
Invasive fungal infections (IFI) remain a major cause of morbidity and mortality in patients (pts) undergoing HCT. The epidemiology of IFI has changed, with a higher proportion of mould infections reported compared to earlier reports (Marr et al. Clin Infect Dis. 2002). The incidence of IFI in children undergoing HCT has been reported at a range of 1.6-25%. The changes in epidemiology of IFI are attributed to multiple factors, including corticosteroid treatment, graft-versus-host disease (GVHD), increase in transplants from alternative donors, and emergence of resistance with use of azoles for IFI prevention.
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