Invasive device-associated hospital infection rates, etiological agents, and their antibiotic susceptibilities in the medical intensive care unit of a university hospital in Turkey

Abstract

To determine the rate, etiological agents, antibiotic susceptibilities, and empirical treatment options of etiological agents of invasive device-associated hospital infections (IDAHIs) in the medical intensive care unit of a university hospital. Materials and methods: Between February 2007 and December 2009, 780 IDAHI cases were evaluated in 1650 patients. Results: Ventilator associated pneumonia, catheter-associated urinary tract infection, and central venous catheter-associated blood stream infection were observed in 415, 242, and 143 IDAHI cases, respectively. The most frequently isolated etiological agents were Acinetobacter spp. in ventilator-associated pneumonia, coagulase-negative staphylococci (CoNS) in central venous catheter-associated blood stream infection, and Candida spp. and E. coli in catheter-associated urinary tract infection. Conclusion: In our study, oxacillin resistance in coagulase-positive S. aureus and CoNS was high. Glycopeptides and linezolid should be considered as treatment options. Resistance of enteric bacteria is defined high against cephalosporin, aminoglycoside, and quinolone. Carbapenems can be considered in the empirical treatment of enteric bacterial infections. Colistin can be given in the treatment of resistant Acinetobacter infections as a therapeutic option. Since antifungal resistance is low, fluconazole should be the first drug of choice in the treatment of candidal infections.