Abstract
Invasive aspergillosisusually occurs in immunocompromised patients, particularly in patients with hematological malignancies because of severe and prolonged neutropenia and/orcytotoxic therapy. Therapy requires antifungal chemotherapy, with lipid-formulations of Amphotericin B or with azoles together with wide surgical excision of the fungal lesion. We report a case of invasive sino-orbital aspergillosis due to Aspergillus fumigatus in a patient with uncontrolled diabetes mellitus and small cell carcinoma. We support the notion that dual immunosuppression due to diabetes and small cell carcinoma with liver metastases was responsible for the invasive form of aspergillosis in this patient.
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