Abstract
Invasion of Intestinal Cells by Staphylococcus aureus is Mediated by Pyruvate Formate Lyase (Pfl) Protein
Highlights
Staphylococcus aureus, a gram-positive and facultative anaerobic bacterium, is a foodborne pathogen that is a global health threat[1]
These results indicate that certain S. aureus strains can invade intestinal cells, and the protein encoded by the pfl gene is involved in this invasion
The results indicated that pyruvate formate lyase (Pfl) protein expression was upregulated in the invasive S. aureus strains, followed by an increase in the levels of elongation factor Tu and phosphopyruvate hydratase in the strains (Table 2)
Summary
Staphylococcus aureus, a gram-positive and facultative anaerobic bacterium, is a foodborne pathogen that is a global health threat[1]. S. aureus is generally found on human skin, and when food is exposed to S. aureus-laden skin, it can result in food contamination and disease. S. aureus can grow and multiply up to 106 CFU/g under optimal growth conditions[2, 3], and produces endotoxins in the food[4,5]. Staphylococcal foodborne illness is caused by consuming food contaminated with S. aureus enterotoxins (SEs), and symptoms of the illness include vomiting and diarrhea[6]. SEs (SEA-SEE, SEG-SEJ, and SER-SET) are heat stable and resistant to low pH. SEA is the most common enterotoxin recovered from foodborne illness outbreaks followed by SED and SEB7,8
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