Abstract
SUMMARY: Chick embryo erythrocytes (CEE) were treated with NaF and KCN to deplete their ATP levels, and their susceptibility toward Toxoplasma gondii invasion was examined. A marked reduction in the invasion rate was observed in ATP-depleted CEE but the rate was recovered in ATP-restored CEE. These results indicate that T. gondii invasion is dependent on the ATP level of the CEE. Consequently, energy-dependent host cell activity is considered to be prerequisite for the invasion of T. gondii.
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