Abstract
The embryonic neural crest offers a unique model system in which to study cell migration mechanisms in vivo during development and disease. The neural crest is a highly invasive, multipotent cell population that displays a regulated spatio‐temporal migratory pattern in the vertebrate embryo. Importantly, several aggressive tumor types, including melanoma and neuroblastoma, originate from neural crest‐derived cells. This has led to the hypothesis that neural crest‐related malignancies may be intrinsically predisposed to increased metastatic potential due to the inherent invasive abilities of the neural crest. I will discuss our recent findings of novel neural crest invasion and inhibitory signals that sculpt the embryonic cell migration pattern and provide insight into limiting metastatic behaviors.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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