Abstract
Cell migration refers to the directional cell movement in response to chemoattractant stimulation. This chapter reports on a biophysics measurement method of migrating cancer cells by using robotic optical tweezers. A cell migration model was also developed by mimicking in vivo migration using optically manipulated chemoattractant-loaded microsources. The model facilitated the quantitative characterization of the relationship among the protrusion force, cell motility, and chemoattractant gradient for the first time. The correctness of the model is verified by using migrating leukemia Jurkat cells. The results show that the ideal migrating capacity can be achieved by the appropriate choice of chemoattractant gradient and concentration at the leading edge of the cell.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
