Abstract
Introduction: Fluid refractory septic shock in adults occurs for the most part as a result of vascular failure. The use of inotropes and vasodilators is infrequent in this setting. Developmental differences in cardiac function could contribute to a different cardiovascular response in pediatric septic shock. We hypothesized that children with fluid refractory septic shock frequently have a high incidence of low cardiac output and high vascular resistance which responds to inotrope and vasodilator therapy.
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