Abstract
This supplement of Kidney International, which contains the Proceedings of the 8th Verona Seminar on Nephrology, is dedicated to all those who believe that the progressive nature of renal diseases is the most fascinating and mysterious topic in nephrology. The aim of this supplement is that of updating our knowledge on the complex mechanisms mediating progression of renal disease and renal failure. Vito M. Campese gives an overview of the neurogenic factors involved in the hypertension of chronic renal failure. Saulo Klahr and Jeremiah Morrissey describe the role of vasoactive compounds, growth factors and cytokines and Agnes B. Fogo offers a critical appraisal of the roles of glomerular hypertension and abnormal glomerular growth in progression of renal disease. The pivotal importance of tubular and interstitial damage in mediating progression is outlined by Leon G. Fine. Francesco Locatelli et al focus on the role of underlying nephropathy, an often neglected but important factor, in affecting progressive deterioration of renal function. Peter Hovind et al draw attention on the role of elevated levels of vascular endothelial growth factor in mediating progressive renal damage in patients with type 1 diabetes. Henk Bos et al consider the role of patient-related factors in the resistance to antiproteinuric interventions both in diabetic and in nondiabetic renal diseases. The symptomatic treatment of chronic renal failure is mainly based on dietary and pharmacological (antihypertensive, lipid lowering) intervention. William F. Keane reviews the role of lipids and treatment of hyperlipidemia in progressive renal diseases. William E. Mitch gives an overview of the role of dietary intervention on both the progression of renal disease and the nutritional impact in uremic patients whereas Carmelita Marcantoni et al outline the advantages of a strict blood pressure control, associated with an antiproteinuric effect, in slowing progression of nondiabetic renal disease. Claudio Ponticelli summarizes the many aspects of chronic rejection and its treatment in renal transplant recipients. Finally, Eberhard Ritz et al offer a look into the future of the most promising methods for counteracting progression of renal disease. We gratefully acknowledge the educational support by Janssen Cilag Italia, which has made the publication of this supplement possible.
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