Abstract
Since their introduction >30 years ago, calcium antagonists have become one of the most widely used classes of pharmacotherapeutic agents for the treatment of hypertension. Of the 20–25 million patients receiving medication for hypertension in the United States, about one-quarter are taking calcium antagonists. Their wide appeal may be attributed to favorable characteristics such as efficacy, metabolic neutrality, and tolerability. 1 Epstein M. Calcium antagonists in the management of hypertension. in: Epstein M. Calcium Antagonists in Clinical Medicine. 2nd ed. Hanley and Belfus, Philadelphia1998: 155-176 Google Scholar , 2 Frishman W.H. Current status of calcium channel blockers. Curr Prob Cardiol. 1994; 19: 637-688 Abstract Full Text PDF PubMed Scopus (46) Google Scholar Some investigations have focused on their possible protective effects on target organs such as the heart and kidney, 3 Epstein M. Calcium antagonists and renal protection Current status and future perspectives. Arch Intern Med. 1992; 152: 1573-1584 Crossref PubMed Scopus (94) Google Scholar , 4 Messerli F.H. McLoughlin M. Cardiac effects of calcium antagonists in hypertension. in: Epstein M. Calcium Antagonists in Clinical Medicine. Hanley and Belfus, Philadelphia1992: 137-150 Google Scholar further enhancing their appealMurray Epstein, MD.
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