Abstract
In this chapter, miniaturization trends in high-throughput screening (HTS) platform and the clinical value of the small-volume HTS platform will be described. After that, difficulties in automation of a massive liquid handling operations in conventional HTS platform will be discussed. Finally, the subject of this dissertation, one-step generation method of large-scale drug-releasing microarray-on-a-chip by self-assembly of encoded drug-laden microparticles (DLPs) will be presented. This technology eliminates the need for an automated liquid handling system for HTS, which has been one of the major bottle-neck for the wide-use of HTS in various research applications.
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