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Highlights
IntroductionWhen kidney functions fail (chronic kidney disease—CKD), this results in a diminished urinary excretion and retention of waste products of metabolism and a gradual decline of almost every function of the body
Introduction to the Toxins SpecialIssue on “Novel Issues in Uremic Toxicity”Raymond VanholderNephrology Section, 0K12, University Hospital, De Pintelaan, 185, B9000 Gent, Belgium; Received: 9 February 2018; Accepted: 14 February 2018; Published: 25 September 2018
In the original experimental study on Advanced Oxidation Protein Products (AOPPs) included in this special issue, it was shown that plasma AOPPs affected the innate immune cell phenotype and function by altering the thiol-redox equilibrium, and in this way may be involved in the migration, accumulation and even proliferation of immune cells such as dendritic cells or macrophages into atherosclerotic plaque, contributing to progression of vascular disease in patients with advanced kidney disease [14]
Summary
When kidney functions fail (chronic kidney disease—CKD), this results in a diminished urinary excretion and retention of waste products of metabolism and a gradual decline of almost every function of the body. In the slipstream of our increasing knowledge of the components exerting uremic toxicity, and as a consequence of the increasing possibilities of biochemistry and molecular biology, our understanding of the mechanisms at the origin of uremic toxicity has been growing In this context, it was decided in 2015–2016 that the journal Toxins would publish a special issue on uremic toxicity that would be devoted to the novel uremic toxins, either newly detected molecules, or well-known solutes with newly detected biological effects. Focus could be as well on identification, biologic effects, generation as on removal or other approaches to decrease concentration It is the intention of this editorial to summarize the content of the 15 publications contained in this special issue. Toxins 2018, 10, 388 of peer-reviewed original publications, one letter to the editor, and one comprehensive review covering the broad overall picture of uremic toxicity
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