Abstract
Recent developments in dental implant have heightened the urgent need to natural tissue adhesives estrogenic materials with ability of promoting the proliferation and osteoblastic differentiation in human dental pulp-derived stem cells, to provide better integration of tissue for dentistry. Up to now, far little attention has been paid to adhesives extract of the root of Ferula sp. which contains biomaterial compounds with estrogenic activities. Prior to undertaking the investigation, analysis of the extract of the root of F. ovina revealed a novel terpenoid, and we identified it as Fenoferin. So far, this paper has focused on Fenoferin compared to Ferutinin and root extract to determine if Fenoferin caused changes in craniofacial cartilage, bone (ceratohyal) and tooth mineralization. Following the purpose of study, we used zebrafish as a well-developed model system for studying bone development, so the developing zebrafish larvae were exposed to various concentration of compounds at 2dpf, and the histological analyses were performed at 6dpf. The result of the current study highlights the importance of F. ovina in studies related to dental regenerative medicine.
Highlights
Introduction to the potential ofFerula ovina in dental implant research due to estrogenic bioactive compounds and adhesive propertiesHoda Zare MirakabadID1*, M
TLC results of concentrated methanol extract of root of F. ovina compared to Ferutinin (Sigma-Aldrich, Oakville, ON, Canada) indicated that Ferutinin appears as the first of four fractions [Fig 2D]
The results of LC-Mass Spectrometric (MS) analysis of Ferula ovina extract compared to Ferutinin is depicted in (S1A and S1B Fig)
Summary
Introduction to the potential ofFerula ovina in dental implant research due to estrogenic bioactive compounds and adhesive propertiesHoda Zare MirakabadID1*, M. Ferula ovina in dental implant research due to estrogenic bioactive compounds and adhesive properties. Periodontal tissue consists of cementum, periodontal ligament (PDL) and alveolar bone. The loss of alveolar bone is responsible for changing the quantity of the alveolar ridge. Since formation of bone defects and the bone remodeling after tooth loss makes dental implant placement difficult or unfeasible depending on the size and location, reestablishment and maintenance of dimensions of the alveolar ridge are essential for a favorable implant [1]. The production of the reliable and predictable methods to stimulate bone regeneration in alveolar bone defects was the focus of studies on dental implant over the last few decades.
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