Abstract
Amyloidosis is a heterogeneous disease that can be challenging to diagnose, frequently eluding even the most astute clinicians. Whether the clinical presentation is primarily cardiac, neurological, gastrointestinal, or renal in nature, symptoms are generally nonspecific and frequently attributed to more common causes of disease without consideration of amyloidosis. The multisystem nature of amyloidosis further complicates diagnosis. While characteristic patterns of multiorgan dysfunction can be a “red flag” finding that points to the correct diagnosis, all too often specialists fail to pick up on abnormal signs or symptoms outside of their own organ system.
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