Introduction to Pediatric NAFLD Series

Abstract

Pediatric nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease in children, and NAFLD has become one of the primary etiologies for liver transplantation in adults. The pediatric prevalence rate is estimated to be 10& in the general population, 25& in obese children, and even higher in severe obesity or in the presence of certain comorbidities. This pediatric NAFLD series, reviews the unique characteristics seen in our pediatric population. It encompasses the most up-to-date epidemiologic and genetic data, takes a closer look at hepatic steatosis and rare diseases that should be considered in infancy and early childhood, and evaluates our current clinical guidelines, available diagnostic modalities, pediatric-specific histological patterns, and attempts to clinically phenotype. Lastly, this touches on the latest treatment options, different diagnostic dilemmas, and the conundrum of pediatric to adult transition. We hope this series serves as a guide in your approach and management in tackling the pressing pediatric NAFLD epidemic.