Abstract
Introduction to mechanisms of neural circuit formation
Highlights
Much progress has been made in recent years toward understanding the underlying causes of neurodevelopmental disorders
The papers in this volume generally fall into three broad areas of developmental neurobiology, including new techniques for the study of these processes: (1) cell adhesion molecules (CAMs) and their downstream roles in cell identity, recognition, and synaptic specificity; (2) axon guidance, formation of terminals, and dendritic arborization; and (3) formation of synaptic structures themselves, the essential final step in circuit formation which, remains subject to remodeling and plasticity throughout development and even in adult animals
The volume opens with a review by Sokolowski and Corbin (2012), highlighting the importance of neuronal circuit formation for behavior through an examination of the development of the limbic circuitry. This is followed by a series of papers on CAMs: a review from Weiner and Jontes (2013), and a hypothesis paper from Yagi (2012) that describe the roles of protocadherins
Summary
Much progress has been made in recent years toward understanding the underlying causes of neurodevelopmental disorders. The papers in this volume generally fall into three broad areas of developmental neurobiology, including new techniques for the study of these processes: (1) cell adhesion molecules (CAMs) and their downstream roles in cell identity, recognition, and synaptic specificity; (2) axon guidance, formation of terminals, and dendritic arborization; and (3) formation of synaptic structures themselves, the essential final step in circuit formation which, remains subject to remodeling and plasticity throughout development and even in adult animals.
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