Abstract

The introduction of highly active antiretroviral therapy (HAART) has dramatically improved the survival of patients infected with human immunodeficiency virus (HIV). However, HAART is complicated by the continuing emergence of drug-resistant strains of HIV and toxicities associated with the antiretroviral agents [, ]. Furthermore, since the combination HAART regimens are incapable of eradicating HIV infection, lifelong therapy is required to avoid disease progression [, ]. Together, these factors necessitate the continual development of new antiretroviral agents that can be utilized against resistant viruses or that in combination with other agents can provide superior viral suppression with less toxicity.

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