Abstract
Introduction: severe sepsis and drotrecogin alfa (activated)
Highlights
Introduction: severe sepsis and drotrecogin alfaAntonio Artigas1 and Claude D Martin2Critical Care 2007, 11(Suppl 5):S1Despite continuing advances in intensive care medicine, severe sepsis and septic shock are currently among the most common causes of morbidity and mortality in intensive care
Clinical trials conducted over more than half a century aimed at reducing the high acute morbidity and mortality rates associated with severe sepsis have shown that recombinant human activated protein C, or drotrecogin alfa, is a treatment that reduces the overall mortality rate in patients with severe sepsis
Vangerow and coworkers [10] describe the predictive value of plasma protein C levels in sepsis. They describe the usefulness of this biomarker for identifying those patients with severe sepsis who are most likely to benefit from recombinant human activated protein C (rhAPC) and for helping the clinician to measure the response to rhAPC. This hypothesis is currently being tested in RESPOND (Research Evaluation Serial Protein C levels in severe sepsis patients On Drotrecogin alfa [activated]) a worldwide phase II study
Summary
Introduction: severe sepsis and drotrecogin alfa (activated)Antonio Artigas1 and Claude D Martin2Critical Care 2007, 11(Suppl 5):S1 (doi:10.1186/cc6180)Despite continuing advances in intensive care medicine, severe sepsis and septic shock are currently among the most common causes of morbidity and mortality in intensive care. Clinical trials conducted over more than half a century aimed at reducing the high acute morbidity and mortality rates associated with severe sepsis have shown that recombinant human activated protein C (rhAPC), or drotrecogin alfa (activated), is a treatment that reduces the overall mortality rate in patients with severe sepsis.
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