Abstract
The 1980s comprised a period in which our understanding of the immunology of infection and, specifically, severe conditions known as ARDS, was being expanded. It was the 1980 classic study by Hammerschmidt and colleagues1 in Lancet that described the association between complement activation and elevated plasma C3a levels with ARDS that alerted many clinicians to this syndrome and an ability to better diagnose it. Management was an altogether different matter.
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