Abstract
Diverse functional groups were introduced in isoquinolines under microwave-assisted palladium- or copper-catalyzed coupling reactions, which include functional groups to isoquinoline were achieved with 1-substituted 4- and 7-bromoisoquinolines, arylboronic acids, terminal alkenes, terminal alkynes, and azaheterocycles. 1,4- or 1,7-Disubstituted isoquinolines were obtained in moderate to excellent yields within 1 h under microwave irradiation. The facile functional group modification of isoquinoline core could establish isoquinoline compound library for drug discovery.
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