Introducing Sculptra®: Global Restoration For The Aging Face

Abstract

Changes in facial appearance with aging include increased prominence of lines and folds, dermal thinning and facial lipoatrophy. Additionally, cheeks can flatten, jowls become prominent, temples hollow and nasolabial and marionette lines appear. These changes can negatively impact self-esteem and, as such, cosmetic enhancement is often sought to re-establish a youthful appearance. There are several injectable agents currently available to help correct the signs of facial aging. Injectable poly-L-lactic acid (PLLA) is a biocompatible, biodegradable synthetic polymer device that, following injection, is hypothesized to elicit fibroblast production and subsequent collagen formation. Treatment with injectable PLLA has been observed to produce considerable increases in dermal thickness, with results lasting for up to 2 years, and longer in some cases. Furthermore, with correct reconstitution and administration, injectable PLLA demonstrates a favorable safety profile. This article reviews the use of injectable PLLA for global rejuvenation of the aging face, including reconstitution and administration techniques that can help optimize outcomes.