Abstract
Introducing a Developed Model of Reversible Cardiac Arrest to Produce Global Brain Ischemia and Its Impact on Microtubule-Associated Protein Tau Phosphorylation at Ser396
Highlights
Stroke and cardiac arrest (CA) are the leading causes of death [1,2,3], but in the survivors of this ischemic injury, it is linked to an increased risk of cognitive and memory impairment [4,5] including the long-term effects of dementia [5]
The findings show the efficiency of this technique in providing a tool to study the further neuronal response to ischemic situations and the underlying mechanisms
Animals were divided to control group and ischemia groups (2 min CA, 2 min CA followed by 60 min reperfusion and 4 weeks recovery, 4 min CA followed by 60 min reperfusion, 8 min CA followed by 120 min reperfusion: n = 4 in each group)
Summary
Stroke and cardiac arrest (CA) are the leading causes of death (approximately 800,000 case of stroke and 400,000 out of hospital CA per year in the U.S.) [1,2,3], but in the survivors of this ischemic injury, it is linked to an increased risk of cognitive and memory impairment [4,5] including the long-term effects of dementia [5] In those who survive the initial CA nearly 60% die from neurological events and 30% of them suffer significant memory impairment [6]. Achieving CA, accurate control of ischemia time and control of the variable post resuscitation environment in an animal CA model is challenging due to the poor long-term animals’ survival rates and complications associated with reperfusion
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