Abstract
This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons. It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function. The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function.
Highlights
That the function of the nervous system is to be defined as the product of interacting networks woven by nerve cells has been the central dogma of neuroscience for almost a century
While the variety of forms that nerve cells may display was described in elegant detail by the work of brilliant morphologists of the turn of the century, their most significant contribution was the proposal of the neuron doctrine
From a physiological point of view the neuron doctrine was considered for a long time to signify a unity of excitability, where the variance among the different neurons related to their shape and connectivity, but not to their individual electrophysiological properties
Summary
Intrinsic electrical properties of mammalian neurons and CNS function: a historical perspective. National Academy of Sciences of Ukraine, Ukraine. This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons. It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function.
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