Abstract
The intrinsic lipid curvature C0 is an important parameter for the stored elastic energy strain in membranes and plays a substantial role in lipid/protein interactions. We explored a model-based approach for C0 determination applying a full q-range small-angle X-ray scattering data analysis of inverted hexagonal phases. The technique was tested on different phosphatidylethanolamines and mixtures of dioleoyl phosphatidylethanolamine with diverse lamellar phase forming lipids, including phosphatdiylcholines of various hydrocarbon chain composition, as well as sphingomyelin. For these mixtures, we included a non-linearity term for lipid mixtures based on the effective lipid headgroup size. We discuss advantages and challenges of our approach and present results for intrinsic curvatures of lipids previously not accessible from experiment.
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