Abstract
In recent studies we and others have identified the cellular proteins PML, hDaxx, Sp100 and ATRX, which form a subnuclear structure known as nuclear domain 10 (ND10) or PML nuclear bodies (PML-NBs), as host restriction factors that counteract cytomegalovirus infections by inhibiting the initiation of viral immediate-early (IE) gene expression. The antiviral function of ND10, however, is antagonized by viral regulatory proteins which either induce a proteasomal degradation of ND10 proteins or a disruption of the subnuclear structure. This review will summarize our current knowledge on the inhibition of cytomegalovirus replication by ND10 proteins. Furthermore, viral strategies to defeat this host defense mechanism are discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
