Abstract
Objectives: To evaluate the efficacy of locally administered vancomycin (VCM) powder for prophylaxis of SSI after invasive lumber spine surgery.Material and Method: This prospective study was conducted upon 85 patients at American international institute of medical science, Udaipur (Rajasthan). All patient were operated for invasive spine surgery from May 2019 to April 2020 and follow up was done for minimum one year of duration. In patients of the VCM group (n = 42), 1 gm VCM powder was locally administered in the surgical wound and Patients who did not receive VCM treatment were set as a control group (n = 43). We compared the patient’s background, Operation time, Intraoperative blood loss, usage of implants, presence of deep SSI, and side effects between the two groups.Results: There were no significant differences between the groups in age, gender, and BMI. The operation time and the intraoperative blood loss were longer and greater in the VCM group than in the control group. Implants were used in 85% of the VCM group, and in 31% of the control group (P< 0.001). Deep SSI was observed in one patient (2.38%) of the VCM group, whereas it was observed in 3 patients (6.97%) in the control group. No systemic side effects of vancomycine were observed in any of the cases.Conclusion: Administration of intrawound VCM powder might be effective to prevent SSI in cases with high risks of infection.
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