Abstract
We read the article by Dr Takano and associates on the effect of intravitreal plasmin on the activation of endogenous matrix metalloproteinase-2 (MMP-2) in human and rabbit vitreous. 1 Takano A. Hirata A. Inomata Y. et al. Intravitreal plasmin injection activates endogenous matrix metalloproteinase-2 in rabbit and human vitreous. Am J Ophthalmol. 2005; 140: 654-660 Abstract Full Text Full Text PDF PubMed Scopus (45) Google Scholar We appreciate the elegant experimental approach elucidating the cleaving effect of plasmin at the vitreoretinal interface, and we congratulate the authors on their work. ReplyAmerican Journal of OphthalmologyVol. 141Issue 4PreviewWe appreciate Drs Gandorfer and Kampik interest in our article and thank them for their comments. Regarding the time course of plasmin-related effects, Gandorfer and associates1 have investigated the ultrastructure of the vitreoretinal interface 30 and 60 minutes after plasmin administration in eyes of freshly slaughtered pigs and found that the most complete vitreoretinal separation consistent with a bare inner limiting membrane was achieved 60 minutes after injection of 2 U of porcine plasmin. Full-Text PDF
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