Abstract
The working mechanism of intravesical electrical stimulation (IVES) was evaluated in α-chloralose anaesthetized cats and rats. IVES involved a direct activation of bladder mechanoreceptor afferents of the Aδ type and as a consequence a central reflex activation of the detrusor. The detrusor response was abolished by bilateral transection of the S1–S3 dorsal roots and by intravesical instillation of lidocaine. The optimal stimulation frequency was 20Hz. The results offer a theoretical rationale for the use of IVES as treatment of weak detrusor contractility in man.
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