Abstract
The majority of strokes are due to blockage of an artery in the brain by a blood clot. Prompt treatment with thrombolytic drugs can restore blood flow before major brain damage has occurred. We report the case series of all patients who were treated with rt-PA at Stroke Unit of HASSAN II University hospital between 2010 and 2013. There were 52 patients treated with intravenous rtPA during the study period. The mean age was 63 years with the no gender predominance (sex ratio 1.02). Hypertension was the most common vascular risk factor (31%) and 17% of patients suffered from atrial fibrillation. 17 of 52 patients (32.7%) were treated within a 3 hours window of stroke onset and 35 of 52 (67.3%) patients were treated within 3-4.5 h. Twenty five patients (48%) had significant early improvements within 24 hours and twenty one (40.3%) patients had good outcomes at 3 months and fifteen patients (29%) died within the same period.
Highlights
Stroke is one of the leading causes of disability and death in both developing and developed countries
We report the case series of thrombolytic therapy in Morocco
Hypertension was the most common vascular risk factor (31%) and 17% of patients suffered from atrial fibrillation. 17 of 52 patients (32.7%) were treated within a 3 hours window of stroke onset and 35 of 52 (67.3%) patients were treated within 34.5 h
Summary
Stroke is one of the leading causes of disability and death in both developing and developed countries. About 22 million people have a stroke world-wide. The prevalence rate of stroke survivors in Morocco is 292/100.000 [3]. Intravenous thrombolytic therapy has been widely recommended as a standard treatment for acute ischemic stroke in most clinical practice guidelines. With the approval of tissue plasminogen activator (rt-PA) for the acute ischemic stroke management, the evolution of this emergency has changed dramatically. Lack of infrastructure is main barriers of thrombolysis therapy in developing countries [4, 5]. On 2007, the first stroke unit in Morocco was created in university hospital of Fez, and the first thrombolysis was done on 2010. We report the case series of thrombolytic therapy in Morocco
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