Abstract
In 2003, the EMEA approved the use of intravenousthrombolysis with rt-PA (Actilyse®) for therapy of acuteischaemic stroke within three hours from system onset,under the condition that these patients are treated accord-ing to the SITS-MOST protocol (Safe Implementation ofThrombolysis for Stroke - MOnitoring STudy - http://www.acutestroke.org) and referred to the SITS-MOST reg-istry. Since then, thrombolytic treatment is offered tostroke patients in Greece in a limited number of centers.
Highlights
In 2003, the EMEA approved the use of intravenous thrombolysis with rt-PA (Actilyse®) for therapy of acute ischaemic stroke within three hours from system onset, under the condition that these patients are treated according to the SITS-MOST protocol (Safe Implementation of Thrombolysis for Stroke - MOnitoring STudy - http:// www.acutestroke.org) and referred to the SITS-MOST registry
Median baseline NIHSS (National Institute of Health Stroke Scale) score was 9. 14 patients had large vessel disease, 3 suffered from cardiogenic embolic stroke, and 8 patients had a lacunar stroke. 18 of the 25 patients experienced quick and lasting amelioration of their deficits, 4 patients remained in unaltered neurological condition, and two patients died from space-occupying extended ischaemic stroke
Three months after the stroke, 19 out of 22 surviving patients were functionally independent, with a score of 0 - 2 on the modified Rankin Scale. These results are strikingly similar to those reported from the SITS-MOST study [1]
Summary
In 2003, the EMEA approved the use of intravenous thrombolysis with rt-PA (Actilyse®) for therapy of acute ischaemic stroke within three hours from system onset, under the condition that these patients are treated according to the SITS-MOST protocol (Safe Implementation of Thrombolysis for Stroke - MOnitoring STudy - http:// www.acutestroke.org) and referred to the SITS-MOST registry. Thrombolytic treatment is offered to stroke patients in Greece in a limited number of centers
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