Intravenous self-administration of nicotine: With and without schedule-induction

Abstract

In Experiment I, rhesus monkeys were trained to lever press on a concurrent fixed-interval 5-min (food pellets) fixed-ratio 1 (IV nicotine-injection) schedule of reinforcement. All three monkeys self-administered nicotine (0.1–100 μg/kg/injection) at two or more doses during the concurrent conditions (Concurrent I or II) at rates that exceeded saline control or rates of nicotine-maintained responding on a simple fixed-ratio 1 schedule (No Food condition). At least one dose of nicotine did maintain FR 1 responding which was greater than saline rates on the single component schedule and these rates were not increased by the addition of a concurrent schedule of food reinforcement. During the concurrent schedule, nicotine-maintained responding occurred throughout the 60-min session in contrast to the No Food (FR 1) condition where most injections of nicotine were self-administered during the initial segments of the session. In general, nicotine injections occurred during the early portions of the interval, although this varied between individual animals. In Experiment II, rhesus monkeys were trained to lever press for intravenous injections of cocaine (50 μg/kg/injection) on a fixed-ratio 10 schedule of reinforcement. During testing, doses of nicotine (1–300 μg/kg/injection) or saline were substituted for cocaine. Nicotine maintained FR 10 responding at rates that exceeded saline self-administration at one or more doses in all four monkeys. These doses were similar to those that functioned as positive reinforcers in Experiment I. These two experiments demonstrate that nicotine can function as a positive reinforcer to maintain FR 1 or FR 10 responding. Experiment I also showed schedule-induction by a concurrent food reinforcement schedule of the self-administration of low doses of nicotine which did not maintain responding on the simple FR 1 schedule, indicating an interaction between environmental factors (schedule of food reinforcement) and pharmacological properties of a drug.