Intravenous perfluorocarbons increased oxygen delivery/ consumption in ARDS in swine

A Scultetus,L Dickson,A Haque,R Mahon,G Mcnamee,F Arnaud,C Auker,R Mccarron

doi:10.1186/cc13523

Abstract

Emulsified perfluorocarbons (PFC) are synthetic hydrocarbons that can carry 50 times more oxygen than human plasma. Their properties may be advantageous in applications requiring preservation of tissue viability in oxygen-deprived states, which makes them a potential candidate for combat and civilian prehospital resuscitation. Our hypothesis was that an intravenous dose of PFC increases vital organ tissue oxygenation, improves survival and reduces or prevents the development of ventilator-associated ARDS. Here we report data from the second part (ARDS only) of a multiphase swine study to investigate the benefits of PFC in treating hemorrhagic shock and preventing ARDS.

Highlights

We aimed to audit the prescribing practice on a busy 14-bedd general ICU, and develop standardised practices and tools to improve safety
Pediatric pharmacists have been an integral part of the PICU rounds since 2002, their role has evolved over the course of years
From 1 January 2003 through 31 December 2012 pharmacists made 24,207 clinical interventions in the PICU and 19,252 of those interventions resulted in changes in medication therapy or therapy monitoring

Summary

Introduction

We aimed to audit the prescribing practice on a busy 14-bedd general ICU, and develop standardised practices and tools to improve safety. The objective of our study was to implement a Post Arrest Consult Team (PACT) and improve the quality of care for admitted OHCA patients This retrospective audit evaluated adult patients who suffered in-hospital cardiac arrest (IHCA) against the recent National Confidential Enquiry into Patient Outcome and Death (NCEPOD) report [1]. It looked at the recognition of the acutely unwell, the interventions made, the decisions taken from admission through to the post-arrest period and the outcomes following cardiopulmonary resuscitation (CPR). Methods We conducted a chart review of all patients admitted to the Department of Critical Care (DCC) at our hospital following cardiac arrest over 2 years in 2010 to 2012 (Group 1). Methods A retrospective review was conducted looking at SICU patients managed with a normothermia protocol, with particular

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