Intravenous paracetamol was associated with closure of the ductus arteriosus in extremely premature infants.

Abstract

Symptomatic patent ductus arteriosus may lead to serious complications in extremely preterm and extremely low birthweight infants and is often resistant to medication. We evaluated early intravenous paracetamol for pain prevention during respiratory therapy, in an attempt to understand the ductal treatment of such infants. Our cohort were 295 extremely preterm or extremely low birthweight infants, born at less than 28weeks or 1000g, respectively, who were treated in the neonatal intensive care unit of Oulu University Hospital from 2002 to 2015, before and after intravenous paracetamol was introduced in June 2009. Ductal closure dates, paracetamol medication details, morbidities and mortality data were evaluated. Intravenous paracetamol was given to 128 infants, starting at a median of 4.4hours age (range: 0-169hours), with a mean total dosage of 212mg/kg (range: 7.5-1175mg/kg). We also included 167 controls who were mainly treated before we used intravenous paracetamol. Ibuprofen (p<0.001) and ligation (p=0.002) were lower in the paracetamol group than controls. No adverse effects were detected. Paracetamol was not associated with other morbidities. We found that early use of intravenous paracetamol decreased the incidence of ductal therapies in extremely premature or extremely low birthweight infants.