Abstract
Introduction: Perioperative pain management is indicated to relieve patient complaints, allow early mobilization after surgery, reduce the duration of hospital stay, and provide a better level of satisfaction. This study aims to describe the use of magnesium sulfate in post-laparotomy patients.
 Case presentation: There were two cases, and the first was a 41-year-old female patient with endometrial cysts and adenomyosis who underwent laparotomy under general anesthesia. The patient was given magnesium sulfate 30 mg/kgBW 20 minutes before induction, then a continuous dose via a syringe pump 10 mg/kgBW/hour until the operation was completed. This patient showed an NRS scale 1 hour after surgery 1/10 and after 24 hours a maximum of 3/10. The second case was a 42-year-old female patient with suspected Leimiosarcoma who underwent a total hysterectomy and bilateral salpingoovorectomy under general anesthesia. Patients also received the same administration of magnesium sulfate and were assessed on the NRS scale up to 2 hours postoperatively 1/10 and after 24 hours a maximum of 2/10.
 Conclusion: Magnesium sulfate is used as an adjuvant in postoperative analgesia and analgesic therapy to treat acute or chronic pain and has antinociceptive effects due to NMDA receptor blocking, making it useful for the prevention of central sensitization.
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