Abstract
Background and objects: Neuromyelitis optica (NMO) is an idiopathic, severe, demyelinating disease of the central nervous system that preferentially affects the optic nerve and spinal cord. Anti-aquaporin 4 antibody seropositive optic neuritis (ON) including NMO spectrum disorders is often severe, bilateral and recurrent. The prognosis of seropositive ON is worse than for multiple sclerosis (MS). Intravenous methylprednisolone pulse therapy (IVMP) for MS is ineffective for NMO. Our study is to clarify the effect of intravenous immunoglobulin (IVIG) for acute seropositive ON.
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