Abstract
Background: Postoperative pain can have a significant effect on patient recovery. Studies suggest that 82% patients experience some pain following surgery, of those 47% complaining of moderate pain, 39% experiencing severe to very severe pain. The failure to adequately treat postoperative pain is due to limitations of monotherapy with opioid analgesics. Intravenous ibuprofen is a nonsteroidal antiinflammatory drug with anti-inflammatory, antipyretic, and analgesic properties that may be related to prostaglandin synthetase inhibition and have been shown to reduce opioid requirements with better postoperative pain management. This paper reviews analgesic outcomes of intravenous ibuprofen as an adjunct to opioid for acute postoperative pain in adults.Methods: Relevant studies were searched using cochrane database of systematic reviews, embase and pubmed databases using key words about intravenous ibuprofen and postoperative pain that were appropriate to each database.Results: Tools to assess pain intensity such as visual analog scale, verbal response scale and self-report of pain scores at rest and with movement have been studied. Multimodal approach with preemptive use of nonsteroidal anti-inflammatory drugs for treatment of postoperative pain is considered.Conclusion: Randomized controlled trials and other studies concluded that postoperative pain control protocols can now consider inclusion of intravenous ibuprofen as an adjunct in multimodal approach to offer patients a significant analgesic benefit while reducing the risks associated with opioid administration.Journal of Society of Anesthesiologists of Nepal 2015; 2(1): 21-24
Highlights
Postoperative pain is the most important concerns of patients during recovery
The concept of multimodal analgesia is targeted for good postoperative pain relief and it has emerged through understanding of benefits of the synergistic effect of multiple drugs.[9]
We conducted our search on randomized clinical trials on IV ibuprofen in postoperative pain management using Cochrane Database of Systematic Reviews, EMBASE and PUBMED databases using appropriate key words for each database from 2009 till 2013.We found three randomized clinical trials on iv ibuprofen alone and one comparison of iv ibuprofen with combination of iv ibuprofen, acetaminophen and caffeine
Summary
Postoperative pain is the most important concerns of patients during recovery. About 80% of patient experience postoperative pain.[1] In order to improve quality of postoperative health care it is important to understand patient’s attitude and concern about postoperative pain.[2] Postoperative pain is an acute pain. Multimodal approach has been taken into consideration and has been practiced for 36 years.[7] The failure to treat acute postoperative pain adequately in one part may be due to the use of monotherapy with opioids.[8] The concept of multimodal analgesia is targeted for good postoperative pain relief and it has emerged through understanding of benefits of the synergistic effect of multiple drugs.[9] Various analgesics act on different sites of nervous system resulting in synergistic analgesia with reduction in side effects of sole agent.[7]. This paper reviews analgesic outcomes of intravenous ibuprofen as an adjunct to opioid for acute postoperative pain in adults
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