Abstract
A total of 302 units of a commercially prepared fat emulsion was given to twenty-eight patients. During five of the infusions, reactions such as nausea, chills and urticaria occurred. These were very minor and the patients showed no untoward effects when reinfused with fat emulsion on the following day. After eighteen infusions in various patients a benign rise in temperature to above 100.6 ° f. was noted. Only one patient showed a serious response. This consisted of jaundice after twenty-four infusions. At the present time it appears that moderate quantities of fat emulsion are safe for clinical use, but large quantities may evoke a severe response. Interference with liver function and the coagulation mechanism after intravenous fat emulsion infusions over a prolonged period is the primary problem requiring further study. Metabolic balance studies were carried out on several patients. Data on six typical patients show the protein-sparing effect of intravenous fat emulsion. This preparation appears to be a useful adjunct in injured patients and other patients who are unable to take adequate calories by mouth.
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