Abstract
Following a period in which the opportunity was given for morphine sulfate self-administration by rats, the effects of substituting an ethyl alcohol solution for morphine were examined. Rats which had acquired the morphine self-administration behavior readily switched to ethyl alcohol. Rats that did not acquire morphine self-administration did not respond for ethyl alcohol. The results indicate that this paradigm is a suitable animal model for the analysis of interrelationships between states of dependence toward opiates and alcohol.
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